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Monday, April 23, 2018

The role of 'extra' DNA in cancer evolution and therapy resistance

https://ift.tt/eA8V8J Researchers tracked genomic alterations detected in patient samples during tumor cell evolution in culture, in patient-derived xenograft (PDX) mouse models from the cultures, as well as before and after treatment in patients. The team reports that tumor progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA.

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