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Monday, April 16, 2018

Formidable duo: Protective effect of CD9 and CD81 in COPD and accelerated aging

https://ift.tt/eA8V8J Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, but the mechanism remains unclear. Researchers studied the aging-like phenotype and its underlying mechanisms in a COPD mouse model. Double deletion of tetraspanins CD9 and CD81 in epithelial cells downregulated expression of the protein SIRT. As SIRT1 is a key molecule that protects against various lifestyle-related diseases and aging, these tetraspanins may serve as novel therapeutic targets for COPD and aging.

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