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Thursday, February 22, 2018

Cancer risk associated with key epigenetic changes occurring through normal aging process

http://ift.tt/eA8V8J Some scientists have hypothesized that tumor-promoting changes in cells during cancer development -- particularly an epigenetic change involving DNA methylation -- arise from rogue cells escaping a natural cell deterioration process called senescence. Now, researchers have demonstrated that instead, tumor-associated epigenetic states evolve erratically during early stages of tumor development, eventually selecting for a subset of genes that undergo the most changes during normal aging and in early tumor development.

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