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Tuesday, February 27, 2018

Axons grip and slip their way around the brain

http://ift.tt/eA8V8J Brain development depends on axons migrating from one location to another by haptotaxis. L1-CAM is responsible for detecting laminin in the environment to regulate the haptotaxis. Scientists have discovered a new mechanism in which L1-CAM grips and slips on laminin to direct axon to its final destination. Loss of this mechanism corresponded with mutations in the L1-CAM protein of CRASH syndrome patients.

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